Gestational trophoblastic neoplasia and disorders of thyroid function
نویسندگان
چکیده
منابع مشابه
Gestational trophoblastic neoplasia.
Trophoblastic neoplasms are a truly fascinating set of diseases that arise from a failed gestation. A molar pregnancy is an allograft of fetal tissue typically containing only paternal chromosomes that may invade the maternal decidua following a failed gestation that may have arisen up to decades earlier. Choriocarcinoma (CCA), the most common malignant form of trophoblastic disease, represente...
متن کاملManagement of gestational trophoblastic neoplasia
It is just 100 years since Marchand [1] identified choriocarcinoma as a tumour arising from placental villous trophoblast. Earlier description of similar tumours failed to identify their tissue of origin. Gestational Trophoblastic Disease (GTD) is the terminological umbrella now used to span the spectrum of cellular proliferations ranging from villous forms of hydatiform mole through invasive m...
متن کاملEvaluation of maternal thyroid autoimmune status in gestational trophoblastic disorders
Hyperthyroidism or increased thyroid function has been reported in many patients with trophoblastic tumors, either hydatidiform mole or choriocarcinoma (1). In the US, hydatidiform mole occurs between 0.5 and 2.5 per 1000 pregnancies (2). It is more common in Asian and Latin American countries (3). Hydatidiform moles secrete large amounts of human chorionic gonadotropin (hCG), and the hCG level...
متن کاملEfficacy of combination therapy of Methotrexate and Vitamin A in low risk gestational trophoblastic neoplasia treatment
Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...
متن کاملSpontaneous regression of gestational trophoblastic neoplasia
•We present two cases of postmolar gestational trophoblastic neoplasia (GTN).•Both cases presented with lung metastases after hydatidiform mole.•Both cases showed spontaneous regression without treatment.•The mechanism behind this phenomenon remains unclear.•Patients with postmolar GTN and declining hCG values may not need chemotherapy.
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ژورنال
عنوان ژورنال: Journal of Endocrinology, Metabolism and Diabetes of South Africa
سال: 2008
ISSN: 1608-9677,2220-1009
DOI: 10.1080/22201009.2008.10872173